Postdoctoral researcher in computational design of protein libraries and testing
- Req. Number: IRC132328
- Organization : 3BIOMB/ MICROBIAL AND BIOME SCIENCES
- City, State: Los Alamos, New Mexico
What You Will Do
You will work with a medium sized team of talented coworkers, towards developing high throughput design and screening of proteins with predetermined functions. Some aspects of the work require performing computational design of protein sequences and backbones. You will help design large libraries of sequences to display on yeast surface and evaluate their function. You will help design computational/experimental workflow for targeted protein-protein interactions. Your high throughput experimental evaluation will not only speed up discovery of functional proteins, but also provide us with valuable data to learn from.
What You Need
Minimum Job Requirements:
1.Background in one or more field such as protein biochemistry, protein modeling and structure biology
2.Experience in designing computationally informed libraries, building and testing in a high throughput set up
3.Strong record of communication via publications (in peer-reviewed journals) and presentations in conferences
Education/Experience: PhD in Biological Sciences or related field with emphasis on protein biochemistry and biophysics
Desired Qualifications: Two or more qualifications from below highly recommended
1. Experience in Python scripting
2.Exposure to computational protein modeling tools such as Rosetta, AlphaFold, ProteinMPNN and RFdiffusion
3.Data assisted learning (Machine learning, Deep learning) and applications to protein design
4. Proficiency in molecular biology and building of genetic libraries
5.Exposure to high throughput protein production and evaluation
6.Experience to experimental methods in protein-protein interaction
7.Protein based therapeutics or diagnostics
8.Exposure to flow cytometry and high throughput screening assay design and implementation; for example, yeast surface display for engineered peptides
Essential Job Functions (can perform with or without reasonable accommodation):
Work Environment:
Work Location:
The work location for this position is onsite (in person) and located in Los Alamos, NM.
Salary: Competitive salaries are based on the date the PhD degree requirements were completed or the degree was awarded. Starting salary for a new graduate is currently $94,500. For more information go to Postdoc Program website at https://www.lanl.gov/careers/career-options/postdoctoral-research/index.php .
Note to Applicants:
No significant travel required. Position is for on-site (preferred)/hybrid work
Where You Will Work
Located in beautiful northern New Mexico, Los Alamos National Laboratory (LANL) is a multidisciplinary research institution engaged in strategic science on behalf of national security. Our generous benefits package includes:
Additional Details
Position does not require a security clearance. The selected candidate will be subject to drug testing and other pre-employment background checks.
New-Employment Drug Test: The Laboratory requires successful applicants to complete a new-employment drug test and maintains a substance abuse policy that includes random drug testing. Although New Mexico and other states have legalized the use of marijuana, use and possession of marijuana remain illegal under federal law. A positive drug test for marijuana will result in termination of employment, even if the use was pre-offer.
Equal Opportunity: Los Alamos National Laboratory is an equal opportunity employer and supports a diverse and inclusive workforce. All employment practices are based on qualification and merit, without regard to race, color, national origin, ancestry, religion, age, sex, gender identity, sexual orientation or preference, marital status or spousal affiliation, physical or mental disability, medical conditions, pregnancy, status as a protected veteran, genetic information, or citizenship within the limits imposed by federal laws and regulations. The Laboratory is also committed to making our workplace accessible to individuals with disabilities and will provide reasonable accommodations, upon request, for individuals to participate in the application and hiring process. To request such an accommodation, please send an email to applyhelp@lanl.gov or call 1-505-665-4444 option 1.
You will work with a medium sized team of talented coworkers, towards developing high throughput design and screening of proteins with predetermined functions. Some aspects of the work require performing computational design of protein sequences and backbones. You will help design large libraries of sequences to display on yeast surface and evaluate their function. You will help design computational/experimental workflow for targeted protein-protein interactions. Your high throughput experimental evaluation will not only speed up discovery of functional proteins, but also provide us with valuable data to learn from.
What You Need
Minimum Job Requirements:
1.Background in one or more field such as protein biochemistry, protein modeling and structure biology
2.Experience in designing computationally informed libraries, building and testing in a high throughput set up
3.Strong record of communication via publications (in peer-reviewed journals) and presentations in conferences
Education/Experience: PhD in Biological Sciences or related field with emphasis on protein biochemistry and biophysics
Desired Qualifications: Two or more qualifications from below highly recommended
1. Experience in Python scripting
2.Exposure to computational protein modeling tools such as Rosetta, AlphaFold, ProteinMPNN and RFdiffusion
3.Data assisted learning (Machine learning, Deep learning) and applications to protein design
4. Proficiency in molecular biology and building of genetic libraries
5.Exposure to high throughput protein production and evaluation
6.Experience to experimental methods in protein-protein interaction
7.Protein based therapeutics or diagnostics
8.Exposure to flow cytometry and high throughput screening assay design and implementation; for example, yeast surface display for engineered peptides
Essential Job Functions (can perform with or without reasonable accommodation):
Work Environment:
Work Location:
The work location for this position is onsite (in person) and located in Los Alamos, NM.
Salary: Competitive salaries are based on the date the PhD degree requirements were completed or the degree was awarded. Starting salary for a new graduate is currently $94,500. For more information go to Postdoc Program website at https://www.lanl.gov/careers/career-options/postdoctoral-research/index.php .
Note to Applicants:
No significant travel required. Position is for on-site (preferred)/hybrid work
Where You Will Work
Located in beautiful northern New Mexico, Los Alamos National Laboratory (LANL) is a multidisciplinary research institution engaged in strategic science on behalf of national security. Our generous benefits package includes:
- PPO or High Deductible medical insurance with the same large nationwide network
- Dental and vision insurance
- Free basic life and disability insurance
- Paid maternity and parental leave
- Award-winning 401(k) (6% matching plus 3.5% annually)
- Learning opportunities and tuition assistance
- Flexible schedules and time off (paid sick, vacation, and holidays)
- Onsite gyms and wellness programs
- Extensive relocation packages (outside a 50 mile radius)
Additional Details
Position does not require a security clearance. The selected candidate will be subject to drug testing and other pre-employment background checks.
New-Employment Drug Test: The Laboratory requires successful applicants to complete a new-employment drug test and maintains a substance abuse policy that includes random drug testing. Although New Mexico and other states have legalized the use of marijuana, use and possession of marijuana remain illegal under federal law. A positive drug test for marijuana will result in termination of employment, even if the use was pre-offer.
Equal Opportunity: Los Alamos National Laboratory is an equal opportunity employer and supports a diverse and inclusive workforce. All employment practices are based on qualification and merit, without regard to race, color, national origin, ancestry, religion, age, sex, gender identity, sexual orientation or preference, marital status or spousal affiliation, physical or mental disability, medical conditions, pregnancy, status as a protected veteran, genetic information, or citizenship within the limits imposed by federal laws and regulations. The Laboratory is also committed to making our workplace accessible to individuals with disabilities and will provide reasonable accommodations, upon request, for individuals to participate in the application and hiring process. To request such an accommodation, please send an email to applyhelp@lanl.gov or call 1-505-665-4444 option 1.
